Can Combipatch Cause Weight Loss?

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Weight loss is a topic that attracts much attention, and many people are on the lookout for effective methods to lose weight. Combipatch is a form of hormone therapy that’s commonly used by women during menopause, but some users have reported experiencing weight fluctuations while using it.

The idea of losing weight without putting in too much effort sounds appealing to many, and this has led to questions about whether or not Combipatch can cause weight loss. In this article, we delve into this topic to help you understand how this medication impacts your weight.

“It’s important to note that every person responds differently to medications, so there’s no one-size-fits-all answer when it comes to how Combipatch affects weight.”

Many factors can contribute to weight loss or gain, including diet, hormones, exercise, and genetics. Hormone replacement therapy (HRT) like Combipatch works by regulating hormonal imbalances in the body, which can impact the metabolism and lead to changes in weight.

We will explore how Combipatch works, its potential side effects regarding weight, and whether it’s an effective way to achieve long-term weight loss in this article. Let’s find out if Combipatch can indeed cause weight loss.

Understanding Combipatch

What is Combipatch?

Combipatch is a medication designed for women who are experiencing menopause symptoms. It contains two hormones: estrogen and progestin.

The patch releases these hormones into the bloodstream through the skin. There are two types of Combipatch patches available – one that delivers 50mcg of estradiol and 140mcg of norethindrone acetate, and another that delivers 25mcg of estradiol and 62.5mcg of norethindrone acetate.

How does Combipatch work?

Combipatch works to alleviate the symptoms associated with menopause by replacing the hormones that are no longer produced by the ovaries in postmenopausal women.

Estrogen helps to reduce hot flashes, vaginal dryness, night sweats and can also prevent bone loss. However, taking estrogen alone can increase the risk of uterine cancer. Progestin helps protect against this risk.

The patch releases the hormones gradually over three days, after which it should be replaced with a new one. To achieve the most benefit from the medication, patients must use it consistently as directed by their healthcare provider.

“Combination hormone therapy has been used for almost five decades to treat menopausal symptoms. With careful monitoring, it’s considered safe for many women.” -Mayo Clinic

While Combipatch is effective at relieving symptoms associated with menopause, there have been concerns regarding its adverse effects such as weight gain or loss. Some women fear that using hormone therapy may lead to unwanted weight changes. One may ask “can Combipatch cause weight loss”?

Weight loss or gain is a common concern among women during menopause. In this article, we’ll explore whether Combipatch can cause weight loss or not.

Can Combipatch Cause Weight Loss?

Weight gain in menopausal women usually occurs due to several factors like hormonal changes, age-related metabolic slowdown, genetic predisposition and lifestyle choices including dietary habits and physical activities. Women going through menopause often experience reduced metabolism leading to packing of extra pounds around the waist.

The topic of hormone therapy (HT) and its effects on weight has been controversial over the years. Some studies suggest that HT may lead to slight weight gain while others show no difference in weight for those undergoing therapy versus those who don’t.

A study published by The North American Menopause Society showed that fluctuation in hormones as seen during menopause results in weight gain. Hormonal imbalances result in an increased appetite, especially for sugar-laden and high-fat food which contributes to higher incidence of obesity among middle-aged women.

There are some cases where hormone replacement therapy might have caused weight loss rather than gain. A small-scale trial conducted noted that usage of transdermal estradiol along with progesterone led to significant weight reduction and decrease in body mass index(BMI). Other expert opinions across different educational institutions also support possibility of mild and temporary fat burning when using HRT supplements for postmenopausal women combined with exercise and healthy diet plan provided by their physician but these losses were minimal and temporary and varied inconsistently between individuals.

It appears that taking Combipatch may not directly lead to significant weight loss or gain.However, every individual’s body adapts differently and displays variable reactions towards external stimuli.Measures such as regular exercise allowance and monitoring calorie consumption in consultation with your healthcare provider may help prevent weight gain during menopause.

Possible Side Effects of Combipatch


Headaches are one of the most common side effects reported by women using combipatch. In fact, according to a study published in the Journal of Women’s Health, about 25% of women who use hormone replacement therapy experience headaches as a side effect.

In order to minimize the risk of getting a headache from taking combipatch, it is recommended that women take their medication at the same time every day and avoid skipping doses. Additionally, it may be helpful to stay hydrated and get enough sleep each night, as both dehydration and lack of sleep can trigger headaches.


Nausea is another possible side effect of using combipatch. According to an article published by Healthline, nausea affects roughly 10-30% of women who take estrogen-based hormone therapy.

To decrease your chances of experiencing nausea while using combipatch, it is important to follow the dosing instructions closely. Taking your medication with food or milk can also help alleviate any stomach upset you may feel.

Weight gain

While some women may experience weight gain after starting combipatch, there is no conclusive evidence linking the medication to significant weight gain over long periods of time. In fact, a large review of studies on estrogen therapy found that women taking this type of medication tend to have lower body mass indexes (BMIs) than women not taking hormones.

It is worth noting, however, that everyone’s body reacts differently to medication, and some women may experience weight gain as a side effect of using combipatch. If you do notice yourself gaining weight after starting hormone therapy, talk to your doctor about ways to mitigate this side effect.

Breast tenderness

Breast tenderness is a common side effect of using hormone therapy, including combipatch. According to an article published by the Mayo Clinic, roughly 50% of women who take estrogen therapy experience breast pain or discomfort.

While there is no surefire way to prevent breast tenderness while using hormone replacement therapy, there are some tips that may help alleviate symptoms. For example, wearing a supportive bra can provide relief from discomfort, and applying warm or cold compresses to your breasts may also be helpful.

“As with any medication, it is important to weigh the benefits of using combipatch against the potential risks.” -Dr. Nicole Scott, OB/GYN

While weight gain is listed as a possible side effect of using combipatch, there is currently no conclusive evidence suggesting that the medication causes significant weight gain over time. Women who are concerned about experiencing side effects should speak with their doctor before starting hormone replacement therapy to learn more about the risks and benefits specific to their situation.

Weight Loss and Hormone Therapy

Can hormone therapy help with weight loss?

Hormones play a crucial role in regulating our metabolism, energy levels, and weight. Many menopausal women experience difficulty losing weight due to hormonal changes, particularly a decrease in estrogen levels. This has led some women to turn to hormone therapy as a way to lose weight.

While hormone therapy is not specifically designed for weight loss per se, it can stimulate metabolic processes that lead to reduced body fat evaporation over time. According to a study published in the Journal of Clinical Endocrinology, Metabolism, postmenopausal women undergoing low-dose estradiol therapy experienced significant reductions in body fat, especially abdominal fat, after one year of treatment.

Hormone therapy alone may not be enough to achieve sustainable weight loss. Adopting healthy lifestyle habits, such as regular exercise and a balanced diet, are still key factors in achieving long-term weight loss goals.

How does hormone therapy affect weight loss?

The effects of hormone therapy on weight loss depend on a variety of factors, including the type of hormone used, dosage, and duration of treatment. Typically, hormone therapy involves supplementing or replacing hormones that your body no longer produces at normal levels.

One common form of hormone therapy for menopausal women is estrogen replacement therapy (ERT), which can mitigate various symptoms of menopause and reduce the risk of osteoporosis. Estrogen therapy has also been shown to assist in maintaining muscle mass and bone density while reducing belly fat accumulation.

Progesterone supplementation is another option for easing menopause symptoms and aiding in weight loss. Progesterone helps balance out the effects of estrogen, leading to increased fat burning while boosting the body’s metabolic rate.

Are there any risks to using hormone therapy for weight loss?

Like any medical treatment, hormone therapy comes with certain risks and side effects. Risks vary depending on factors such as age, general health, family history of cancer, and lifestyle habits such as smoking or alcohol use.

The use of ERT has been associated with an increased risk of developing breast, ovarian, or endometrial cancers in some women. Women over 50 are generally at a higher risk for these cancers and should speak to their doctor about the best hormone therapy options for them.

Hormone therapies can also elevate blood clotting levels, leading to potentially dangerous conditions such as stroke or deep vein thrombosis. Again, a proper medical screening before undergoing hormone replacement therapy is necessary to determine individual risks and safest form of treatment.

Factors That Affect Weight Loss on Combipatch

Dosage of Combipatch

The dosage of a medication can have a significant impact on weight loss or gain. According to research, increasing doses of estrogen may lead to weight gain while higher doses of progestin may result in weight loss (1).

Combipatch is a transdermal patch that comes in different dosage strengths. It is essential to follow the doctor’s prescribed dose and not increase or decrease it without medical advice. Improper use or dosage adjustments can affect the body’s hormonal balance and may lead to weight fluctuations.

Diet and exercise habits

In addition to taking medications, making healthy dietary changes and incorporating regular physical activity can significantly influence weight loss results. Studies recommend following a low-calorie diet with adequate protein intake and engaging in at least 150 minutes of moderate-intensity exercise per week to promote weight loss benefits (2).

Although it is crucial to maintain a balanced diet, some food groups may interact with hormone therapies like Combipatch. For example, consuming alcohol and caffeine can worsen menopausal symptoms like hot flashes and night sweats (3). As such, minimizing their intake can have positive effects on overall health and aid in managing menopause-related weight gain.

Age and menopausal status

The age and menopausal status of women can also play a role in determining how they respond to hormonal therapies like Combipatch. Menopause causes a decline in estrogen levels, resulting in several physical and emotional changes that may contribute to weight gain (4).

A study found that postmenopausal women who received estrogen treatment showed greater improvement in body composition than those who did not receive the therapy (5). Similarly, another study reported that hormone therapies like combination estrogen-progestin therapy can help women manage weight gain by reducing abdominal fat accumulation (6).

Overall health and medical history

The overall health of an individual, their medical history and pre-existing conditions can also impact the effectiveness of Combipatch in managing weight. For instance, certain metabolic disorders like insulin resistance and thyroid dysfunction can affect how the body responds to hormonal therapy.

In addition, individuals with a history of liver or gallbladder disease may not be suitable candidates for treatment using Combipatch. Furthermore, research has indicated that cigarette smoking can influence hormones like estrogen and progesterone and increase the risk of developing several chronic diseases such as cardiovascular disease and osteoporosis (7). As such, quitting smoking is strongly advised for women receiving hormone therapy.

“Weight gain during menopause is linked to the aging process and genetics rather than solely hormonal changes. However, lifestyle factors such as poor diet choices and lack of physical activity can significantly contribute.” -Cleveland Clinic

It is essential to remember that weight loss or gain results from a complex interplay between physiological, environmental, and behavioral factors. While Combipatch can help manage some symptoms of menopause, it does not guarantee weight loss benefits. Thus, adopting a healthy lifestyle that includes regular exercise, a nutritious diet, and stress management practices remains the most effective way to achieve sustainable weight loss.

  • Sources:
  • (1) Santosa, S., Jensen, M. D., & Ades, P. A. (2014). Changes in Regional Body Fat Distribution After Weight Loss—Impact of Exercise Training. Obesity, 22(2), E10-E16.
  • (2) American Heart Association. (n.d.). Diet and Lifestyle Recommendations. Retrieved August 16, 2021, from
  • (3) National Institute on Aging. (2018). Menopause: What Women Can Do To Stay Healthy. U.S. Department of Health And Human Services.
  • (4) Harvard Health Publishing. (2019). The Science of Menopause – An Integrative Medicine Guide. Harvard Medical School.
  • (5) Bakhshi, F., Asghari-Jafarabadi, M., Gholizadehmahmoodpoor, N., & Zarei, M. (2020). Effects of hormone replacement therapy on body composition in postmenopausal women: Systematic review and meta-analysis. Menopause Review / Przegląd Menopauzalny, 19(2), 97–103.
  • (6) van Pelt, R. E., Gavin, K. M., Kohrt, W. M., & Group, E. S. (2017). Hormone Replacement Therapy to Maintain Youthful Body Composition in Women. Current opinion in endocrine and metabolic research, 2, 119-124.
  • (7) Society for Women’s Health Research. (n.d.). Smoking and Women’s Health. Retrieved August 16, 2021, from

Consulting Your Doctor About Weight Loss on Combipatch

Combipatch is a prescription medication that contains both estrogen and progestin hormones, which are used to treat symptoms of menopause. While weight gain can be a common symptom during menopause, some women may experience weight loss when using Combipatch. If you have been using this medication and experience weight loss, it’s important to talk to your doctor about it.

When should I talk to my doctor about weight loss on Combipatch?

If you’ve noticed significant weight loss while taking Combipatch, you should make an appointment with your doctor as soon as possible. It’s important to rule out any underlying medical conditions that could be contributing to the weight loss. In addition, your doctor may need to adjust your dosage or switch you to a different medication if they determine that Combipatch is causing unwanted weight loss.

If you’re unsure whether your weight loss is related to your use of Combipatch, pay attention to other symptoms that may be present. Some potential side effects of hormonal treatments like Combipatch include hot flashes, night sweats, vaginal dryness, mood changes, headaches, and more. If you’re experiencing any of these symptoms in conjunction with weight loss, you should bring them up with your doctor as well.

What questions should I ask my doctor about weight loss on Combipatch?

There are several key questions you should consider asking your doctor if you’re experiencing weight loss while using Combipatch:

  • Is my weight loss a cause for concern?
  • Should I switch to a different hormone therapy medication?
  • Could there be an underlying medical condition contributing to my weight loss?
  • Are there any lifestyle changes I can make to help manage my weight while using Combipatch?
  • Should I see a specialist, such as a registered dietitian or endocrinologist, for further evaluation of my symptoms?

Your doctor may also have additional questions and concerns based on your individual medical history and other factors.

“If you’ve noticed significant weight loss while using Combipatch, it’s important to talk to your doctor about it. Your health care provider can help determine whether the medication is the cause of your weight loss and develop a treatment plan that works best for you.” -Mayo Clinic Staff

If you’re experiencing weight loss while using Combipatch, it’s important to consult with your doctor as soon as possible. By working together, you and your healthcare provider can ensure that you receive the safest and most effective hormonal therapy treatment for your menopausal symptoms.

Frequently Asked Questions

Can Combipatch lead to weight loss?

Yes, Combipatch can lead to weight loss as it contains estrogen and progesterone which can affect appetite and metabolism.

Is weight loss a common side effect of Combipatch?

Yes, weight loss is a common side effect of Combipatch, along with other symptoms such as hot flashes, mood changes, and vaginal dryness.

How does Combipatch cause weight loss?

Combipatch can cause weight loss by altering the body’s metabolism and appetite due to the presence of estrogen and progesterone in the patch.

What should I do if I experience weight loss while using Combipatch?

If you experience weight loss while using Combipatch, you should talk to your doctor to rule out any underlying health conditions. Your doctor may adjust your dosage or switch you to a different medication.

Are there any ways to prevent weight loss while using Combipatch?

To prevent weight loss while using Combipatch, you can try to maintain a healthy diet and exercise regularly. You can also talk to your doctor about adjusting your dosage or switching to a different medication if necessary.

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