Which biochemical abnormalities may you expect to see in severe cases of anorexia nervosa?

In anorexia nervosa, under-nutrition and weight regulatory behaviours such as vomiting and laxative abuse can lead to a range of biochemical problems. Hypokalaemia is the most common electrolyte abnormality. Metabolic alkalosis occurs in patients who vomit or abuse diuretics and acidosis in those misusing laxatives.

What are 3 physiological changes that occur with anorexia nervosa?

Common signs and symptoms include loss of subcutaneous fat tissue, orthostatic hypotension, bradycardia, impaired menstrual function, hair loss, and hypothermia.

Does anorexia cause acidosis or alkalosis?

Self-induced vomiting is a common feature of the eating disorders anorexia nervosa and bulimia. Because these individuals are losing HCl from stomach secretions, it is not uncommon for them to develop a metabolic alkalosis.

Does anorexia cause metabolic alkalosis?

In anorexia nervosa, under-nutrition and weight regulatory behaviours such as vomiting and laxative abuse can lead to a range of biochemical problems. Hypokalaemia is the most common electrolyte abnormality. Metabolic alkalosis occurs in patients who vomit or abuse diuretics and acidosis in those misusing laxatives.

Can anorexia cause metabolic acidosis?

The onset of a metabolic acidosis in a patient with anorexia nervosa remains very rare, but also exceptionally severe and unknown to physicians. To our knowledge, this is the first reported case of starvation-induced metabolic acidosis in a non-diabetic adolescent with anorexia nervosa.

What do blood tests show for anorexia?

These may include a complete blood count (CBC) and more-specialized blood tests to check electrolytes and protein as well as functioning of your liver, kidney and thyroid. A urinalysis also may be done. Psychological evaluation.

What are the three essential diagnostic features of anorexia nervosa?

  • Restriction of calorie consumption leading to weight loss or a failure to gain weight resulting in a significantly low body weight based on that person’s age, sex, height and stage of growth.
  • Intense fear of gaining weight or becoming “fat.”
  • Having a distorted view of themselves and their condition.

What is the most common medical complication of anorexia?

Cardiac. Bradycardia (pulse

What are 5 physical effects of anorexia?

  • Extreme weight loss or not making expected developmental weight gains.
  • Thin appearance.
  • Abnormal blood counts.
  • Fatigue.
  • Insomnia.
  • Dizziness or fainting.
  • Bluish discoloration of the fingers.
  • Hair that thins, breaks or falls out.

What happens to the body in anorexia nervosa?

Untreated, anorexia nervosa can lead to: Damaged organs, especially the heart, brain, and kidneys. Drop in blood pressure, pulse, and breathing rates. Loss of hair.

Can anorexia cause low glucose?

Food restriction and excessive exercise enacted during anorexia leads to the depletion of glycogen (a form of energy storage), resulting in abnormal glucose metabolism and hypoglycemia (very low levels of blood sugar) (Mayo Clinic, 2018).

Is hypokalemia common in anorexia?

Hypokalemia is frequently found in patients with anorexia nervosa and sometimes leads to life-threatening conditions.

Does anorexia cause low potassium?

The most frequent electrolyte imbalances seen in anorexia are hyponatremia (a low concentration of sodium ions in the bloodstream) and hypokalemia (a low concentration of potassium ions).

Why do anorexics have low potassium?

Inpatients with anorexia nervosa presumably have a higher risk of developing hypokalemia because they suffer from severe malnutrition and are refed [21], in which the insulin surge resulting from glycemia during the refeeding process causes a substantial intracellular uptake of potassium and phosphorus [20].

Can anorexia cause lactic acidosis?

The etiology of lactic acidosis in the reported case is probably multifactorial including hypotension, volume depletion, hypothermia, (all due to anorexia nervosa with the subsequent impairment in renal and hepatic function) and probably metformin overdose. The mortality inreported cases is about 50 percent.

Why does anorexia cause hyponatremia?

Hyponatremia can also be seen in severe restrictive eating disorders due to decreased ability of the kidney to excrete free water as a result of low nutritional intake. Without enough food or solutes, even a fairly normal amount of water intake can lead to hyponatremia if the body retains too much of it.

What other disorders might occur with anorexia nervosa?

  • Anxiety.
  • Depression.
  • Substance abuse/alcohol.
  • Self-injury.
  • Borderline personality disorder (BPD)
  • Obsessive-compulsive disorder (OCD)

Why is bicarbonate high in metabolic alkalosis?

In metabolic alkalosis there is excess of bicarbonate in the body fluids. It can occur in a variety of conditions. It may be due to digestive issues, like repeated vomiting, that disrupt the blood’s acid-base balance. It can also be due to complications of conditions affecting the heart, liver and kidneys.

How does bulimia nervosa cause metabolic alkalosis?

Patients who purge by vomiting may present with metabolic alkalosis (elevated serum bicarbonate levels) due to volume contraction. However, patients who primarily abuse laxatives may present with metabolic acidosis (decreased serum bicarbonate levels) due to loss of alkaline fluid from the bowel.

What eating disorders cause low sodium?

Anorexia nervosa (AN) is a psychiatric disorder characterized by restrictive eating, low body weight, and severe bone loss. Recent data show a deleterious relationship between low circulating sodium levels and bone mass, and relative or absolute hyponatremia is a known complication of AN.

Can bloodwork tell if you have AN eating disorder?

A variety of laboratory tests and bloodwork may be needed to determine the correct eating disorder diagnosis and assess the appropriate level of care for an affected individual. The laboratory tests will evaluate the following types of factors: Blood sugar levels.

Can anorexics have normal blood results?

It is common for bloods to be normal in eating disorders. In fact for some they are normal when critically ill with low heart rate, low blood pressure etc..

Can anorexia cause elevated liver enzymes?

HealthDay News — For adults with severe anorexia nervosa (AN), elevated liver enzymes are relatively common and are associated with lower body mass index (BMI) and hypoglycemia, according to research published online in the International Journal of Eating Disorders.

What are three negative complications of anorexia?

Complications of anorexia include: Death. Anemia. Heart problems, such as mitral valve prolapse, abnormal heart rhythms and heart failure. Bone loss, increasing risk of fractures later in life.

What are the two types of anorexia nervosa?

Anorexia nervosa may be divided into 2 subtypes: Restricting, in which severe limitation of food intake is the primary means to weight loss. Binge-eating/purging type, in which there are periods of food intake that are compensated by self-induced vomiting, laxative or diuretic abuse, and/or excessive exercise.

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